May 1, 2013-May 26, 2014
Typhoid fever is a disease that is prevalent in developing countries. It is transmitted through chronic carrier and contaminated food and water. Its causative typhi is susceptible to antibiotics but report of drug-resistant S. typhi raises alarm s unchecked infection can lead to mortality especially infants and children. the study aimed to investigate the antimicrobial properties of aqeous, alcoholic and n-hexane extract of Theobroma cacao L. seed, seed pulp and seed hull on pure culture of S.typhi. The disc-diffusion assay was used to evaluate its activity with ciprofloxacin as control. Different concentration of the extract (crude extract,75% v/v and 25% v/v) were tested against the organism. Only the crude aqueous extract of the seed pulp and the crude alcoholic extract of the test organism. There was no significant difference (a=0.05) in the zone of inhibition based on the type of extract. On the other hand, there was a significant difference between extract in terms of concentration. The crude extract showed the highest activity out of all treatments. Theobrama cacao seed, seed pulp and seed hull extract did not show any activity against Salmonella typhi.
The study aimed to investigate the utility of Theobroma cacao plant extracts as antimicrobial agents pure cultures of S. typhi.
1. Connor, B A, Schartrz, E , Schwatrz, E . Typhoid and Paratyphoid Fever in Travelers. The Lancet Infectious Diseases 623-628.